C. ELEGANS MALE WIRING PROJECT

ABOUT THIS PROJECT

We are reconstructing connectivity in the C. elegans adult male nervous system from serial section electron micrographs.

Connectivity in the posterior nervous system is being determined from a series of electron micrographs created by N. Thomson and analyzed by D. Albertson at the MRC Laboratory of Molecular Biology, Cambridge, UK, in the 1970's.  This series is designated N2Y in a publication on the hermaphrodite nervous system (White, J. G., Southgate, E., Thomson, J.N., and Brenner, S. (1986) The structure of the nervous system of Caenorhabditis elegans. Philos. Trans. R. Soc. Lond. B. Biol. Sci. 314, 1-340) and is
Series 4 in a publication on the anatomy and development of the male (Sulston, J. E., Albertson D., and Thomson, J. N.  (1980) The Caenorhabditis elegans male:  Postembryonic development of nongonadal structures.  Dev. Biol. 78, 542-576).

The series of electron micrographs used for reconstruction in the tail is comprised of several sections named for the ganglia through which they extend.  These sections include the pre-anal ganglion, dorsorectal ganglion and right and left lumbar ganglia.   A library of serial section EMs, including all those used for this project, is accessible at wormimage.org

Maps and synapse lists are updated periodically as the reconstruction progresses.  Where a non-neuron name appears, such as r4 or br12, these refer to temporary designations of as yet unidentified neurons.  "unk" refers to "unknown" and is often the arm of an as yet unidentified muscle.

The project is supported by the Mathers Foundation of Mt. Kisco, New York.

The following individuals contributed to this project:
Haftan Eckholdt
Michael Zhang
Zara Martirosyan
Aparna Singh
Travis Jarrell
Christopher Brittin
Steven Cook

CITING THIS PROJECT